ABSTRACT
Lidocaine iontophoresis allows for the transfer of lidocaine into the skin under the influence of electric current to provide dermal anesthesia. Recent studies support the use of this technology for anesthesia prior to procedures such as venous access, injection, shave biopsy, and pulse dye laser therapy. This chapter reviews the history, principles, and clinical use of lidocaine iontophoresis for dermatologic procedures. An iontophoretic drug delivery system consists of a power source that provides electrical current, and two electrodes, a drug delivery electrode and a current return electrode. Many patients experience tingling, itching, or warmth during iontophoretic treatment. Erythema occurs after treatment often under the cathode for lidocaine iontophoresis. Urticaria secondary to mast cell activation can also be seen under the electrodes. Petechiae can also occur under the electrode placement areas. Lidocaine iontophoresis is an effective method for topical anesthesia prior to simple dermatologic procedures.
