ABSTRACT
This chapter discusses the use of rodents as they are the most commonly used due to their low cost and because they are a reliable model of human seizures. It provides a more in-depth consideration of the specific details of electroshock techniques, including the rationale for commonly used procedures, electrode placement, electrical current-related variations in the convulsive response, interpretation of the results, and other factors that influence the convulsive response. Electroshock is the generalized electrical stimulation of the brain. Typically an electrical current of less than a second’s duration is passed from one side of the head to the other. The itemization provides a description of the relatively simple technique for administering electroshock convulsions using corneal electrodes in rodents. Electroshock induces a continuum of motor convulsions that are dependent on the intensity of the electrical stimulation current. The maximal tonic-clonic convulsion is the severe electroshock convulsive response and it is induced by supramaximal electrical stimulation currents, known as maximal electroshock.
