ABSTRACT

About a 100 years ago, Coley observed tumor regression after application of a mixture of bacterial toxins. This experiment made the foundation of immune therapy for cancer, which only recently became a promising treatment and an efficient alternative to chemotherapy. In contrast to chemotherapy (1), this new treatment does not kill tumor cells directly; rather it enhances the sensitivity of the patient’s own immune system against tumor cells with all the potential positive aspects like high selectivity of treatment and much less side effects (2).