A Lecture Note On Determination Of Acid Force Of Components Of Synthesis Of 1-[ 2-( .- Acetylmethyl)- 3- .- Acetyl- 2- Ethyl]- Methyldichlorinephosphite

Quantum-chemical calculation of molecule of 1-[2-(о-acetylmethyl)-3-оacetyl-2-ethyl]-methyldichlorinephosphite (I) and components of its synthesis [4] for the first time is executed by method AB INITIO in basis 6-311G**. The optimized geometrical and electronic structures of these compounds are received. Their acid force is theorized. All these compounds concern to a class of very weak С-Н-acids (рКа > 14, where рКа is the universal parameter of acidity). Dependence between acid force of components of synthesis рКа (II) and рКа (III) and acid force рКа (I) a required product is positioned:

Ace ty loxymethy l -2 -ch lo r ine -5 -e thy l -1 ,2 ,3 -d ioxaphosphorynan, acetyl chloride, 1-[2-(о-acetylmethyl)-3-о-acetyl-2-ethyl]- methyldichlorinephosphite1-[2-(о-Acetylmethyl)-3-о-acetyl-2-ethyl]- methyldichlorinephosphite (I) is intermediate substance for reception of a medical product from a hepatitis. It possesses interesting and probably unique properties.