ABSTRACT
One of the promising solutions for this intrinsic depth limitation is the optical clearing method, where a high refractive index hyperosmotic agent is added to the tissue to increase its transparency and to improve signal detection. e most accepted mechanism is via refractive index matching that reduces
8.1 Introduction ......................................................................................169 8.2 Physical Background ........................................................................170 8.3 Monte Carlo Simulations .................................................................172 8.4 Mechanism of Optical Clearing in Muscle ...................................173 8.5 Optical Clearing in Collagenous Tissues ......................................177 8.6 Optical Clearing in Skin ..................................................................180 8.7 Optical Clearing in Kidney Tissue .................................................182 8.8 Alternative Investigation of Optical Clearing: Articial
Environment ......................................................................................184 8.9 Retention of SHG Polarization Signatures through Optical
Clearing ..............................................................................................185 8.10 Final Remarks....................................................................................187 References ......................................................................................................187
