Direct Compression and the Role of Filler-binders

Direct Compression (DC) is the tableting of a blend of ingredients, the compression mix,

without a preliminary granulation or aggregation process. The compression mix contains

the active pharmaceutical ingredient (API) blended with one or more excipients. The

excipients may include binders, filler/diluents, disintegrants, and lubricants. Such DC

compression mixes must flow uniformly into a die and form a robust tablet.