ABSTRACT
Introduction ....................................................................................................................................155 Adipokines, Adipokinomes, Inflammation, and White Adipose Tissue .......................................156 Hypoxia, Cancer, and Angiogenesis ..............................................................................................157 Role of Leptin, Product of the
ob
Gene, in Angiogenesis............................................................157 Antiangiogenic Therapeutic Strategies to Regulate Obesity.........................................................158 Redox Control of Angiogenesis: Oxidants as Inducers
of Angiogenic Factors and Angiogenesis....................................................................................159 Antiangiogenic Function of Antioxidants .....................................................................................160 Antiangiogenic Antioxidant Nutrients ...........................................................................................160 Obesity, Angiogenesis, and Cancer ...............................................................................................161 Conclusions ....................................................................................................................................161 Acknowledgment............................................................................................................................161 References ......................................................................................................................................161
Obesity is now a worldwide epidemic [1-3]. The prevalence of overweight and obesity in the United States and other industrialized and developing countries is increasing exponentially (Table 13.1) [1-6]. Approximately half a billion of the world’s population is now considered overweight (body mass index [BMI], 25-29 kg/m
