ABSTRACT
Protein Therapeutics versus Small Molecule Drugs .............................................. 154 Sources of Protein Therapeutics ................................................................... 155 Targets of Protein Therapeutics and Modes of Action .................................. 155
Engineering Effective Protein Therapeutics .......................................................... 156 Challenges in Pharmaceutical Translation of New Therapeutic Proteins ..... 156 Strategies for Designing Effective Protein Therapeutics .............................. 157
Strategies for Improving Pharmacokinetics ...................................... 157 Strategies for Reducing Immunogenicity ......................................... 158 Genetic Engineering ......................................................................... 159
Examples of Protein Therapeutics ......................................................................... 160 Monoclonal Antibody Therapeutics.............................................................. 161 Enzyme Therapeutics Acting on Extracellular Targets ................................. 161 Protein Therapeutics as Replacements for Defective or Decient Proteins .....162
