ABSTRACT
Interest in oral controlled release dosage forms has brought increasing attention to
multiparticulate modified release systems usually consisting of barrier coated pellets. The
advantages of such multiparticulate systems over single unit peroral sustained release
systems are:
1. Greater statistical assurance of drug release and so more reproducible and constant
drug concentration after oral administration. Therefore, inter-and intrapatient varia-
bility is reduced (1).
