Magnetization Transfer and Chemical Exchange Saturation Transfer Imaging in Cancer Imaging
Typical MRI sequences do not e›ectively encode spatial information for several milliseconds a£er the excitation radiofrequency (RF) pulse. Even ultra short echo time acquisition sequences typically take hundreds of microseconds before acquiring data on clinical imaging systems. Solid macromolecular proton samples, however, have T2 values of roughly 10 μs, meaning that the signals from these samples will have disappeared before any acquisition begins. šese proton spins are not, however, completely invisible. Via MT, these solid proton spins a›ect the imaged water proton spins. še pool of solid proton spins is not directly imaged. Instead, the solid proton spins are indirectly detected via their e›ect on the liquid proton spins.