ABSTRACT

Diseases ............................................................................................248 10.1.2 Historical Overview of Inammatory Phenomena in

Neuropsychiatric Disorders ..............................................................249 10.1.3 Connections between Neuropsychiatric Disorders,

Somatic Disorders, and Inammation ..............................................249 10.1.3.1 Increased Rates of Psychiatric Disease in

Medically Ill Patients .........................................................249 10.1.3.2 Neuropsychiatric Disorders as Risk Factors for the

Development of Medical Illness ........................................250 10.2 Relationship of Inammation to Neuropsychiatric Disease: Mood and

Anxiety Disorders ......................................................................................... 251 10.2.1 Increased Inammation in Major Depression .................................. 251 10.2.2 Increased Inammation in Anxiety Disorders ................................. 252

10.2.2.1 Posttraumatic Stress Disorder ............................................ 253 10.3 Impact of Cytokines on the Brain ................................................................254