ABSTRACT

Mutual compatibility of polymers and solvents is one of the important issues of materials engineering not only in the polymer industry but also for pharmaceuticals, where drug delivery and release is closely related to the properties of the individual components. In simple terms, “like dissolves like,” a principle that can be quanti-žed through the Hildebrand solubility parameter, which is dežned as the square root of the cohesive energy density. The basic concept has been further režned by Hansen [1], who introduced individual terms related to the van der Waals dispersion forces, dipole interaction, and hydrogen bonding. The total solubility parameters and

4.1 Introduction .................................................................................................... 47 4.2 Methodology ................................................................................................... 49 4.3 Results and Discussion ...................................................................................50