ABSTRACT
Introduction 185
Screening Tests for Depigmentation Agents 190
Clinical Evaluation 194
The Case of Kojic Acid 200
References 204
INTRODUCTION
There are a variety of facial pigmentary disorders (Table 1). Among such dis-
eases, malignant tumors should be diagnosed and treated properly because
some of them are quick to develop, destructive, or fatal. Hyperpigmentation of
the face of middle-aged women is most common; however, it is benign, and, if
diagnosed and treated properly, it can be cured or greatly improved.