ABSTRACT
Background .................................................................................................................................... 328 Obesity Drugs: A Historical Prescriptive ....................................................................................... 328
Thyroid Hormone ...................................................................................................................... 328 Dinitrophenol ............................................................................................................................ 329 Amphetamines........................................................................................................................... 329 Rainbow Pills ............................................................................................................................ 329 Aminorex Fumarate .................................................................................................................. 330 Fenˆuramine and Dexfenˆuramine ........................................................................................... 330 Phenylpropanolamine ................................................................................................................ 331 Ephedra ..................................................................................................................................... 331 Rimonabant ............................................................................................................................... 331 Sibutramine ............................................................................................................................... 332
Obesity Drugs Presently Available ................................................................................................ 333 Amphetamine Derivatives ......................................................................................................... 333 Benzphetamine .......................................................................................................................... 334 Diethylpropion .......................................................................................................................... 334 Phendimetrazine ........................................................................................................................ 334 Phentermine............................................................................................................................... 334 Orlistat ....................................................................................................................................... 334
Drugs Approved for Other Reasons That Are Associated with Weight Loss ................................. 335 Bupropion .................................................................................................................................. 335 Exenatide ................................................................................................................................... 335 Bydurion .................................................................................................................................... 336 Liraglutide ................................................................................................................................. 336 Fluoxetine and Sertraline .......................................................................................................... 337 Metformin ................................................................................................................................. 337 Pramlintide ................................................................................................................................ 338 Somatostatin .............................................................................................................................. 338 Topiramate ................................................................................................................................. 339 Zonisamide ................................................................................................................................ 339
Recent Drug Development .............................................................................................................340 Lorcaserin ..................................................................................................................................340 Tesofensine ................................................................................................................................340 Combination Drugs ................................................................................................................... 341 Bupropion + Naltraxone ............................................................................................................ 341 Pramlintide + Metreleptin ......................................................................................................... 341 Phentermine and Controlled-Release Topiramate ..................................................................... 342 Potential for Using Herbs to Develop New Obesity Drugs ....................................................... 342 Discussion and Conclusions ...................................................................................................... 343
References ......................................................................................................................................344
