ABSTRACT
Synonym: Lu AA21004 Trade name: Brintellix (Takeda) Indications: Major depressive disorder Class: Antidepressant, Serotonin receptor agonist, Serotonin receptor antagonist, Serotonin reuptake inhibitor Half-life: ~66 hours Clinically important, potentially hazardous interactions with: bupropion, carbamazepine, fluoxetine, MAO inhibitors, paroxetine, phenytoin, quinidine, rifampin Pregnancy category: C
Skin Hyperhidrosis [2] Pruritus (<3%)
Mucosal Oropharyngeal pain [1] Xerostomia (6-8%) [5]
Cardiovascular Flushing Palpitation [1]
Central Nervous System Abnormal dreams (<3%) [1] Agitation [1] Anxiety [1] Dysgeusia (taste perversion) Headache [9] Hypomania Mania Serotonin syndrome Somnolence (drowsiness) [1] Suicidal ideation Tremor [1] Vertigo (dizziness) (6-9%) [4]
Neuromuscular/Skeletal Asthenia (fatigue) [1]
Gastrointestinal/Hepatic Constipation (3-6%) [1] Diarrhea (7-10%) [2] Dyspepsia [1] Flatulence (<3%) Nausea (21-32%) [10] Vomiting (3-6%) [1]
Respiratory Nasopharyngitis [1]
Endocrine/Metabolic Hyponatremia
Genitourinary Sexual dysfunction (<5%) [3]
Other Adverse effects [2]
