ABSTRACT
Trade name: Coumadin (Bristol-Myers Squibb) Indications: Thromboembolic disease, pulmonary embolism Class: Anticoagulant, Coumarin Half-life: 1.5-2.5 days (highly variable) Clinically important, potentially hazardous interactions with: acemetacin, amiodarone, amobarbital, amprenavir, antithyroid agents, aprepitant, aprobarbital, aspirin, atazanavir, atorvastatin, azathioprine, azithromycin, barbiturates, beclomethasone, betamethasone, bezafibrate, bismuth, bivalirudin, boceprevir, bosentan, butabarbital, capecitabine, cefixime, celecoxib, chondroitin, cimetidine, ciprofloxacin, clarithromycin, clofibrate, clopidogrel, clorazepate, co-trimoxazole, colesevelam, cyclosporine, danazol, daptomycin, darunavir, delavirdine, desvenlafaxine, dexamethasone, dexibuprofen, dexlansoprazole, diclofenac, dicloxacillin, dirithromycin, disulfiram, dronedarone, duloxetine, econazole, efavirenz, elvitegravir / cobicistat / emtricitabine / tenofovir, enzalutamide, ergotamine, erlotinib, erythromycin, eslicarbazepine, etoricoxib, exenatide, fenofibrate, fluconazole, flunisolide, fluoxymesterone, fosamprenavir, gefitinib, gemfibrozil, glucagon, grapefruit juice, heparin, imatinib, influenza vaccine, itraconazole, ketoconazole, leflunomide, lepirudin, levofloxacin, levothyroxine, liothyronine, liraglutide, lomitapide, lopinavir, menadione, mephobarbital, methimazole, methyl salicylate, methylprednisolone, methyltestosterone, metronidazole, miconazole, mifepristone, moricizine, moxifloxacin, nafcillin, nalidixic acid, nandrolone, nilutamide, norfloxacin, ofloxacin, omeprazole, orlistat, pantoprazole, PEGinterferon, penicillin G, penicillin V, penicillins, pentobarbital, phenobarbital, phenylbutazones, phytonadione, piperacillin, piroxicam, prasugrel, primidone, propoxyphene, propranolol, propylthiouracil, quinidine, quinine, rabeprazole, resveratrol, rifampin, rifapentine, rofecoxib, romidepsin, ropinirole, rosuvastatin, roxithromycin, salicylates, secobarbital, simvastatin, sitaxentan, sorafenib, St John’s wort, stanozolol, sulfamethoxazole, sulfinpyrazone, sulfisoxazole, sulfonamides, sulindac, tamsulosin, tegafur / gimeracil / oteracil, telaprevir, telithromycin, teriflunomide, testosterone, tibolone, tigecycline, tinidazole, tolmetin, tolterodine, triamcinolone, troleandomycin, uracil / tegafur, valdecoxib, vemurafenib, venlafaxine, vilazodone, vitamin A, vitamin E, zafirlukast, zileuton Pregnancy category: X (category D for women with mechanical heart valves) Note: Alternative remedies, including herbals, may potentially increase the risk of bleeding or potentiate the effects of warfarin therapy. Some of these include the following: angelica root, arnica flower, anise, asafetida, bogbean, borage seed oil, bromelain, dan-shen, devil’s claw, fenugreek, feverfew, garlic, ginger, ginkgo biloba, ginseng, horse chestnut, lovage root, meadowsweet, onion, parsley, passionflower herb, poplar, quassia, red clover, rue, turmeric and willow bark.
