ABSTRACT
Trade name: Sporanox (Janssen Biotech) (Ortho) Indications: Onychomycosis, deep mycoses, oropharyngeal candidiasis (oral solution only) Class: Antibiotic, triazole, Antifungal, CYP3A4 inhibitor Half-life: 21 hours Clinically important, potentially hazardous interactions with: abiraterone, afatinib, alfentanil, alfuzosin, aliskiren, alprazolam, amphotericin B, amprenavir, anisindione, antacids, aprepitant, aripiprazole, artemether / lumefantrine, astemizole, atazanavir, atorvastatin, avanafil, boceprevir, bosentan, budesonide, buspirone, busulfan, cabazitaxel, cabozantinib, calcium channel blockers, carbamazepine, cerivastatin, ciclesonide, cilostazol, cimetidine, cinacalcet, cisapride, clarithromycin, clopidogrel, clorazepate, colchicine, conivaptan, corticosteroids, coumarins, crizotinib, cyclophosphamide, cyclosporine, cyproterone, dabigatran, darifenacin, dasatinib, dexamethasone, diazepam, dicumarol, didanosine, digoxin, dihydropyridines, disopyramide, docetaxel, dofetilide, dronedarone, efavirenz, eletriptan, elvitegravir / cobicistat / emtricitabine / tenofovir, enzalutamide, eplerenone, ergotamine, erlotinib, erythromycin, estradiol, ethotoin, everolimus, felodipine, fentanyl, fesoterodine, fluticasone propionate, fosamprenavir, fosphenytoin, gefitinib, grapefruit juice, halofantrine, haloperidol, histamine H2-antagonists, HMGCoA reductase inhibitors, iloperidone, imatinib, indinavir, isoniazid, ivabradine, ixabepilone, lapatinib, lercanidipine, levomethadyl, lomitapide, lopinavir, lovastatin, mephenytoin, methylergonovine, methylprednisolone, methysergide, micafungin, midazolam, mifepristone, mizolastine, nevirapine, nilotinib, nisoldipine, omeprazole, oral hypoglycemics, paclitaxel, paliperidone, pantoprazole, pazopanib, phenobarbital, phenytoin, pimecrolimus, pimozide, ponatinib, prednisolone, prednisone, proton pump inhibitors, quetiapine, quinidine, ranolazine, reboxetine, regorafenib, repaglinide, rifabutin, rifampin, rilpivirine, rimonabant, ritonavir, rivaroxaban, romidepsin, ruxolitinib, saquinavir, sildenafil, silodosin, simeprevir, simvastatin, sirolimus, solifenacin, sunitinib, tacrolimus, tadalafil, telaprevir, temsirolimus, terfenadine, ticagrelor, tolterodine, tolvaptan, triamcinolone, triazolam, trimetrexate, ulipristal, vardenafil, vemurafenib, vinblastine, vincristine, vinflunine, vinorelbine, warfarin Pregnancy category: C Note: Contraindicated in patients with evidence of ventricular dysfunction such as congestive heart failure (CHF) or a history of CHF except for the treatment of life-threatening or other serious infections.
