ABSTRACT
Insight into the dynamic behavior of molecules and particles in biomaterials is an important aspect in many research areas. In cell biology, for example, it has become clear that techniques are required for s tudying t he i ntracellular t ransport o f mole cules si nce t he c ell o rganization h as p roven to b e a highly dy namic process (Levi and Gratton 2007). A lso in t he biomedical and pharmaceutical elds, the mobility of molecules and particles is an important aspect because the successful delivery of (macromolecular) therapeutics, such as proteins and polynucleotides, depends on the mobility of drug molecules during the several phases of the delivery process in the human body (Sanders et al. 2000). To that end, intelligent carrier materials capable of protecting the therapeutic molecules against degradation and facilitating their transport in extracellular and intracellular matrices are being developed (Remaut et al. 2007).
