ABSTRACT
From the 1960s to the present day, there have been a number of estimates of absorbed dose in the nuclear medicine literature. Most of these calculations refer to diagnostic clinical studies, although a few of the reports concern animals and patients receiving therapeutic amounts of various agents. This chapter emphasizes therapeutic dose estimates; most of the latter are examples of radioimmunotherapy (RIT). Specifically, we discuss applications in which there is either no manifest positive correlation of clinical outcome with estimated absorbed dose or no attempt to obtain such an analysis. We defer to Chapter 9 those relatively few literature studies in which there is a correlation between absorbed organ dose and effect. The latter examples, although decidedly in the minority, are very significant to the development of improved dose estimation techniques. Hence, we emphasize those reports in their own segment of the text.
