ABSTRACT
>95% of penile cancers are squamous cell carcinoma.
Circumcision virtually eliminates the risk of penile cancer. Other factors associated with increased risk include HPV, smoking, and poor hygiene.
Evaluation of a penile tumor includes physical exam (particularly of inguinal lymph nodes), biopsy, and abdominal-pelvic CT or MRI.
Treatment of penile cancer is based on T stage, size, and proximal extent of tumor. Surgical treatment options range from circumcision and local excision to anterior exenteration.
Inguinal lymph nodes are the most common site for metastases.
Patients presenting with adenopathy should receive a 6-week course of antibiotics. If adenopathy persists after treatment, lymphadenectomy is indicated.
