ABSTRACT

PART 1: INTRODUCTION Ischemic diabetic foot ulcer is the main cause of nontraumatic amputations in western countries (1).

For patients aged 65 to 74 years, diabetes heightens the risk of amputation more than 20-fold, putting these patients at great risk of limb loss; 20% of subjects with diabetes develop a foot ulcer in the course of life, and 33% of them, if untreated, frequently undergo amputation (2-5).