ABSTRACT
Multiple sclerosis most frequently affects the optic nerve and chiasm, brain stem, cerebellum and the cervical spinal cord. The presence of spondylosis often contributes to the formation of plaques in that region. This preferential involvement determines the frequency of the signs and symptoms observed in MS patients (Table 1). Because it is often difficult, especially on the basis of patient history, to separate symptoms from signs, the clinical features listed in Table 1 are presented as symptom/sign combinations.
