ABSTRACT
Hypoglycaemic unawareness occurs in 25% of longstanding diabetics and is due to impaired adrenergic responses. There is no current evidence to suggest that human insulin increases this phenomenon.
Sulphonylureas (stimulate insulin secretion), those drugs with a long half-life (e.g. chlorpropamide), a prolonged action on the beta-cells (e.g. glibenclamide) or drugs excreted via the kidneys (if there is renal impairment) are prone to cause hypoglycaemia.
