Screening in the NanoWorld: Single-Molecule Spectroscopy and Miniaturized High-Throughput Screening

A. A Rationale for New Methods in Drug Discovery The dramatic increase simultaneously, in the number of targets and the potential hit compounds is the reason for what has been called a change in paradigm in drug discovery [1]. To capitalize fully on the promise of both genomics and combinatorial chemistry, the drug discovery process must change in a fundamental way.