ABSTRACT
Erythema multiforme Exanthems (1999): Smith HR+, Clin Exp Dermatol 24, 249 (30%) Exfoliative dermatitis (1993): Martin GJ+, Clin Infect Dis 16, 341 Facial dermatitis (1991): Shlim DR, JAMA 266, 2560 Pruritus (1999): Smith HR+, Clin Exp Dermatol 24, 249 (4-10%) (1989): Sowunmi A+, Lancet 2, 313; 397 Psoriasis (1998): Potasman I+, J Travel Med 5, 156 Rash (sic) (1-10%) Stevens-Johnson syndrome (1999): Smith HR+, Clin Exp Dermatol 24, 249 (1991): Van den Enden E+, Lancet 337, 683 Toxic epidermal necrolysis (1999): Smith HR+, Clin Exp Dermatol 24, 249 (fatal) (1997): McBride SR+, Lancet 349, 101 Urticaria (1999): Smith HR+, Clin Exp Dermatol 24, 249 Vasculitis (1999): Smith HR+, Clin Exp Dermatol 24, 249 (1995): White AC+, Ann Intern Med 123, 894 (1993): Scerri L+, Int J Dermatol 32, 517
Hair Hair-alopecia (<1%)
Other Death
Depression (2002): van Riemsdijk MM+, Clin Pharmacol Ther 72(3), 294 Headache Myalgia (1-10%) Tinnitus
Scientific name: N-acetyl-5-methoxytryptamine Family: None Trade and other common names: MEL; MLT Category: Chemoprotectant; Circadian rhythm regulator Purported indications and other uses: Jet lag, sleep disorders, Alzheimer’s disease,
free radical scavenger, chemotherapy adjunct, tinnitus, depression, migraine, cluster headache, hypertension, hyperpigmentation, osteoporosis, antioxidant. Skin protectant against sunburn
Half-life: N/A Clinically important, potentially hazardous interactions with: acetaminophen,
NSAIDs, warfarin, zoloft
Reactions
Skin Fixed eruption
(2001): Morera AL+, Actas Esp Psiquiatr 29(5), 334 (2 cases) (1998): Bardazzi F+, Acta Derm Venereol 78(1), 69 Photosensitivity (1999): Haga HJ+, Lupus 8(4), 269
Other Confusion
(2001): Morera AL+, Actas Esp Psiquiatr 29(5), 334 (overdose) Crohn’s disease (2002): Calvo JR+, J Pineal Res 32(4), 277 Seizures (2001): Morera AL+, Actas Esp Psiquiatr 29(5), 334 (4 cases)
