ABSTRACT
Purpura (1952): Sneddon IB+, BMJ 1, 1276 (1946): Grant Peterkin GA, BMJ 2, 52 Pustules (generalized) (1991): Kleier RS+, Arch Dermatol 127, 1361 Rash (sic) (<1%) Stevens-Johnson syndrome (<1%) (1999): Duncan KO, J Am Acad Dermatol 40, 493 (at sites of radiation therapy) (1999): Rzany B+, Lancet 353, 2190 (1995): Labandiera-Garcia J, An Med Interna (Spanish) 12, 569 (1995): Wolkenstein P+, Arch Dermatol 131, 544 (1994): Koukoulis A+, An Med Interna (Spanish) 11, 311 (1993): Leenutaphong V+, Int J Dermatol 32, 428 (1992): Lleonart R+, Med Clin (Barc) (Spanish) 99, 474 (1985): Avery JK, J Tenn Med Assoc 78, 764 (1985): de Rego JA+, Hillside J Clin Psychiatry 7, 141 (1982): Brahams D, Lancet 2, 1474 (1982): Oles KS+, Clin Pharm 1, 565 (1971): Adeloye A+, Ghana Med J 10, 56 Toxic epidermal necrolysis (2000): Devidal R+, Therapie 55, 225 (2 cases) (1999): Rzany B+, Lancet 353, 2190 (1996): Blum L+, J Am Acad Dermatol 34, 1088 (1995): Wolkenstein P+, Arch Dermatol 131, 544 (1994): Errani A+, Br J Dermatol 131, 586 (1994): Shelley WB+, Cutis 53, 162 (observation) (1993): Correia O+, Dermatology 186, 32 (1993): Leenutaphong V+, Int J Dermatol 32, 428 (1989): Dominguez-Perez F+, Rev Esp Anestesiol Reanim (Spanish) 36, 350 (1988): Shear NH+, J Clin Invest 82, 1826 (1987): Teillac D+, Arch Fr Pediatr (French) 44, 583 (1985): de Rego JA+, Hillside J Clin Psychiatry 7, 141 (1984): Chan HL, J Am Acad Dermatol 10, 973 (1975): Deviller G+, Union Med Can (French) 104, 399 (1975): Giallorenzi AF+, Oral Surg Oral Med Oral Pathol 40, 611 (1973): Stüttgen G, Br J Dermatol 88, 291 (1966): Campos EC de+, An Bras Dermatol (Portuguese) 41, 165 (1966): Haraszti A+, Orv Hetil (Hungarian) 107, 2133 (fatal) (1966): Kaczorowska-Hanke H+, Przegl Dermatol (Polish) 53, 197 Toxicoderma (sic) (1998): Arima M+, Jpn Circ J 62, 132 Urticaria (1940): Moss RE+, Arch Dermatol 46, 386 Vasculitis
Hair Hair-depigmentation
(1992): Mion N+, Ann Dermatol Venereol (French) 119, 927
Nails Nails-hypoplasia
(1991): Thakker JC+, Indian Pediatr 28, 73 (1990): Holder M+, Monatsschr Kinderheilkr (German) 138, 34
Other Acute Intermittent porphyria
(2001): Sykes RM, Seizure 10(1), 64 Death DRESS syndrome (2001): Lachgar T+, Allerg Immunol (Paris (Paris) 33(4), 173 (1997): Descamps V+, Br J Dermatol 137, 605 Headache Hypersensitivity (<1%)* (2002): Metin A+, World Congress Dermatol Poster, 0116 (1999): Moss DM+, J Emerg Med 17, 503 (1998): Chapman MS+, Br J Dermatol 138, 710
*Note: The antiepileptic drug hypersensitivity syndrome is a severe, occasionally fatal, disorder characterized by any or all of the following: pruritic exanthems, toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, fever, hepatic abnormalities, eosinophilia, and renal failure
(1998): Schlienger RG+, Epilepsia 39, S3 (passim) (1997): Morkunas AR+, Crit Care Clin 13, 727 (1992): Nagata T+, Jpn J Clin Oncol 22, 421 (1984): Fonseca JC+, Med Cutan Ibero Lat Am (Spanish) 12, 187 Hypoplasia of phalanges (1991): Thakker JC+, Indian Pediatr 28, 73 (1990): Holder M+, Monatsschr Kinderheilkr (German) 138, 34 Injection-site bullous eruption (1987): Haroun M+, Cutis 39, 233 Injection-site pain (>10%) Injection-site thrombophlebitis (>10%) Oral ulceration Porphyria cutanea tarda (1966): Ziprkowski L+, Isr J Med Sci 2, 338 Porphyria variegata Rhabdomyolysis (1990): Larpin R+, Presse Med 19(30), 1403 Xerostomia
(1952): Sneddon IB+, BMJ 1, 1276
Trade names: Agoral; Alophen; Caroid; Correctol; Doxidan; Espotabs; Evac-U-Gen; Ex-Lax (Novartis); Feen-A-Mint; Medilax; Phenolax; Prulet; Trilax
Other common trade names: Bom-Bon; Bonomint; Darmol; Easylax; Purganol; Ruguletts
Indications: Constipation Category: Laxative Half-life: N/A
Reactions
Skin Angioedema
(1972): Grillat JP+, Rev Fr Allergie (French) 12, 351 Builous eruption (1974): Magill M+, Med J Aust 1,771 Diaphoresis Erythema annulare (sic) (1972): Grillat JP+, Rev Fr Allergie (French) 12, 351 Erythema multiforme (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
344 (1972): Shelley WB+, Br J Dermatol 86, 118 Exanthems (1972): Grilliat JP+, Rev Fr Allergol (French) 12, 351 (1969): Török H, Dermatol Int 8, 57 Exfoliative dermatitis (1973): Nicolis GD+, Arch Dermatol 108, 788 Fixed eruption (1997): Blumenthal HL, Beachwood, OH (personal case) (observation) (1993): Zanolli MD+, Pediatrics 91, 1199 (1991): Smoller BR+, J Cuton Pathol 18, 13 (1990): Gaffoor PMA+, Cutis 45, 242 (1987): Stroud MB+, Arch Dermatol 123, 1227 (1986): Kanwar AJ+, Dermatologica 172, 315 (1985): Kauppinen K+, Br J Dermatol 112, 575 (1984): Chan HL, Int J Dermatol 23, 607 (1978): Sehgal VN+, Int J Dermatol 17, 78
(1972): Hunziker N, Rev Med Suisse Romande (French) 92, 237 (1972): Louis P, Z Haut Geschlechtskr (German) 47, 387 (1972): Shelley WB+, Br J Dermatol 86, 118 (bullous) (1972): Wyatt E+, Arch Dermatol 106, 671 (1970): Savin JA, Br J Dermatol 83, 546 (1969): Török H, Dermatol Int 8, 57 (1967): Schulz KH+, Z Haut Geschlechtskr (German) 42, 561 (1964): Browne SG, BMJ 2, 1041 Lupus erythematosus (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
344 Perianal irritation Pigmentation (1973): Levantlne A+, Br J Dermatol 89, 105 Pruritus (1972): Grillat JP+, Rev Fr Allergie (French) 12, 351 Stevens-Johnson syndrome (1972): Monnat A, Schweiz Med Wochenschr (French) 102, 1876 Toxic epidermal necrolysis (1997): Artymowicz RJ+, Ann Pharmacother 31, 1157 (1986): Kar PK+, J Indian Med Assoc 84, 189 (1973): Björnberg A, Acta Dermatol Venereol (Stockh) 53, 149 (1973): Khamadullin LG, Vestn Dermatol Venerol (Russian) 47, 67 (1972): Monnat A, Schweiz Med Wochenschr (French) 102, 1876 (1967): Lowney ED+, Arch Dermatol 95, 359 (1966): Témime P+, Bull Soc Fr Dermatol Syphiligr (French) 73, 305 (1961): Browne SG+, BMJ 1, 550 (1957): Lang R+, S Afr Med J 31, 713 Urticaria (1972): Grillat JP+, Rev Fr Allergie (French) 12, 351
Nails Nails-discoloration
(1984): Daniel CR+, J Am Acad Dermatol 10, 250
Other Oral mucosal fixed eruption
Oral mucosal pigmentation Oral mucosal ulceration
