ABSTRACT
Trade name: Alurate (Roche) Indications: Short-term sedation, sleep induction Category: Barbiturate Half-life: 14-34 hours Clinically important, potentially hazardous interactions with: alcohol,
brompheniramine, buclizine, dicumarol, ethanolamine, warfarin
Reactions
Skin Angioedema
Exanthems Exfoliative dermatitis Purpura Rash (sic) Stevens-Johnson syndrome Urticaria
Other Rhabdomyolysis
(1990): Larpin R+, Presse Med 19(30), 1403 Serum sickness
Trade name: Trasylol (Bayer) Indications: For prophylactic use to reduce blood loss in patients undergoing coronary
artery bypass surgery Category: Hemostatic (natural protease inhibitor) Half-life: 150 minutes
Reactions
Skin
Allergic reactions (sic) (0.5%) (1994): Bayo M+, Rev Esp Anestesiol Reanim (Spanish) 41, 123 (1983): Freeman JG+, Curr Med Res Opin 8, 559 (2 cases) Angioedema Erythema Exanthems (2000): Beierlein W+, Transfusion 40, 302 (generalized) Pruritus Rash (sic) Urticaria
Other Anaphylactoid reactions (0.5%)
(2001): Dietrich W+, Anesthesiology 95(1), 64 (2000): Beierlein W, Ann Thorac Surg 69, 1298 (2000): Laxenaire MC+, Ann Fr Anesth Reanim (French) 19, 96 (2000): Pecquet C+, Ann Fr Anesth 19(10), 755 (1999): Cohen DM+, Ann Thorac Surg 67, 837 (1999): Laxenaire MC, Ann Fr Anesth Reanim (French) 18, 796 (4 cases) (1999): Ong BC+, Anaesth Intensive Care 27, 538 (1999): Ryckwaert Y+, Ann Fr Anesth Reanim (French) 18, 904 (1998): Scheule AM+, Gastrointest Endosc 48, 83 (1997): Dietrich W+, J Thorac Cardiovasc Surg 113, 194 (1997): Orsel I+, Ann Fr Anesth Reanim (French) 16, 292 (1997): Scheule AM+, Ann Thorac Surg 63, 242 (1996): Martinelli L+, Ann Thorac Surg 61, 1288 (1995): Ceriana P+, J Cardiothorac Vasc Anesth 9, 477 (1995): Diefenbach C+, Anesth Analg 80, 830 (1994): Kon NF+, Masui (Japanese) 43, 1606 (1993): Cottineau C+, Ann Fr Anesth Reanim (French) 12, 590 (1993): Schulze K+, Eur J Cardiothorac Surg 7, 495 (2 patients) (1984): BMJ 289, 1696 (1984): LaFerla GA+, BMJ 289, 1176 (1976): Proud G+, Lancet 2, 48 (1971): Bauer J+, Am J Gastroenterol 56, 542 Hypersensitivity (2002): Jaquiss RD+, Circulation 106(12 Suppl 1), 190 (2000): Beierlein W+, Transfusion 40, 302 (1998): Dietrich W, Ann Thoracic Surg 65, S60 (1.8%) (1975): Ariani G+, Minerva Anestesiol (Italian) 41, 138 Lipohypertrophy (1985): Boag F+, N Engl J Med 312, 245 (in a diabetic) (1985): Dandona P+, Diabetes Res 2, 213 (in a diabetic) Phlebitis (1-10%) Shock (sic)
(1971): Vashchuk VV, Klin Med (Mosk) (Russian) 49, 128
Trade name: GenESA (Gensia) Indications: Diagnostic aid for coronary artery disease Category: Adrenergic agonist; Nonradioactive diagnostic synthetic catecholamine Half-life: 1.8 hours Clinically important, potentially hazardous interactions with: abacavir, clidinium,
clomipramine, desipramine, dicyclomine, digoxin, doxepin, flavoxate, glycopyrrolate, hyoscyamine, imipramine, methantheline, nortriptyline, oxybutynin, procyclidine, propantheline, protriptyline, scopolamine, trihexyphenidyl, trimipramine
Reactions
Skin Diaphoresis (1.5%)
Flushing (3%) (2001): Wright DJ+, Nucl Med Commun 22(12), 1305 (35%) Hot flashes (3%) Rash (sic)
Other Application-site reactions (0.1%)
Back pain (0.1%) Cough (0.2%) Dysgeusia (1.3%) (2001): Wright DJ+, Nucl Med Commun 22(12), 1305 (23%) Hyperesthesia (1.0%) Pain (1.8%) Paresthesias (2%) Tremor (15%) (1997): Cohen A+, Am J Cardiol 79(6), 713 (5.6%) Twitching (0.3%) Xerostomia (1.1%)
