ABSTRACT
Dermatitis (sic) (1991): Renaut JJ, Allerg Immunol Paris (French) 23, 365 Diaphoresis Ecchymoses (<1%) Edema Erythema (1991): Renaut JJ, Allerg Immunol Paris (French) 23, 365 Erythema multiforme (<1%) (1987): Jeanmougin M+, Ann Dermatol Venereol (French) 114, 1400 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1985): O’Brien WM+, J Rheumatol 12, 13 (1984): Stern RS+, JAMA 252, 1433 (1982): Park GD+, Arch Intern Med 142, 1292 (1981): Husain Z+, J Rheumatol 8, 176 (1981): Maguire FW, Del Med J 53, 193 (1980): Russell IJ, Ann Intern Med 92, 716 Exanthems (1-5%) (1993): Litt JZ, Beachwood, OH (personal case) (observation) (1991): Hyson CP+, Arch Intern Med 151, 387
(1987): Jeanmougin M+, Ann Dermatol Venereol (French) 114, 1400 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1984): Stern RS+, JAMA 252, 1433 (1982): Park GD+, Arch Intern Med 142, 1292 (1981): Dhand A+, Gastroenterology 80, 585 (1980): Russell IJ, Ann Intern Med 92, 716 (1979): Anderson R, N Engl J Med 300, 735 (1977): Calabro JJ+, Clin Pharmacol Ther 22, 358 (3%) Exfoliative dermatitis (<1%) Exfoliative erythroderma (1984): Stern RS+, JAMA 252, 1433 Facial erythema (1979): Anderson R, N Engl J Med 300, 735 Fixed eruption (<1%) (1987): Jeanmougin M+, Ann Dermatol Venereol (French) 114,1400 (1986): Bruce DR+, Cutis 38, 323 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1984): Aram H, Int J Dermatol 23, 421 (1984): Stern RS+, JAMA 252, 1433 Hot flashes (<1%) Jaundice (1979): Wolfe PB, Ann Intern Med 91, 656 Lichen planus (1983): Hamburger J+, BMJ 287, 1258 Pernio (1981): Reinertsen JL, Arthritis Rheum 24, 1215 Photosensitivlty (<1%) (1987): Jeanmougin M+, Ann Dermatol Venereol (French) 114, 1400 (1984): Stern RS+, JAMA 252, 1433 Phototoxicity Pruritus (1-10%) (1987): Jeanmougin M+, Ann Dermatol Venereol (French) 114, 1400 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1984): Stern RS+, JAMA 252, 1433 (1982): Park GD+, Arch Intern Med 142, 1292 (1980): Russell IJ, Ann Intern Med 92, 716 Purpura (<1%) (1987): Jeanmougin M+, Ann Dermatol Venereol (French) 114, 1400 (1984): Stern RS+, JAMA 252, 1433 Rash (sic) (>10%) Raynaud’s phenomenon (1981): Reinertsen JL, Arthritis Rheum 24, 1215 (passim) Skin pain (sic) (1984): Stern RS+, JAMA 252, 1433 Stevens-Johnson syndrome (<1%)
(1993): Awaya N+, Ryumachi (Japanese) 33, 432 (1983): Klein SM+, J Rheumatol 10, 512 (1981): Husain Z+, J Rheumatol 8, 176 (1981): Maguire FW, Del Med J 53, 193 (1980): Levitt L+, JAMA 243, 1262 Toxic epidermal necrolysis (<1%) (1990): Hovde O, Tidsskr Nor Laegeforen (Norwegian) 110, 2537 (1988): Small RE+, Clin Pharm 7, 766 (1987): Ikeda N+, Z Rechtsmed (German) 98, 141 (1987): Jeanmougin M+, Ann Dermatol Venereol (French) 114, 1400 (1986): Rodt SA+, Tidsskr Nor Laegeforen (Norwegian) 106, 2982 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1985): Chevrant-Breton JC, Therapie (French) 40, 67 (1985): Heng MCY, Br J Dermatol 113, 597 (1984): Stern RS+, JAMA 252, 1433 (1983): Klein SM+, J Rheumatol 10, 512 (1982): Park GD+, Arch Intern Med 142, 1292 (1980): Levitt L+, JAMA 243, 1262 (1980): Russell IJ, Ann Intern Med 92, 716 Urticaria (<1%) (1987): Jeanmougin M+, Ann Dermatol Venereol (French) 114, 1400 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1984): Stern RS+, JAMA 252, 1433 (1981): Burrish G+, Ann Emerg Med 10, 154 Vasculitis (<1%)
Hair Hair-alopecia (<1%)
Other Ageusia (<1%)
Anaphylactoid reactions (<1%) (1991): Hyson CP+, Arch Intern Med 151, 387 (1985): O’Brien WM+, J Rheumatol 12, 13 (1981): Burrish G+, Ann Emerg Med 10, 154 (1980): Smith F+, JAMA 244, 269 Aphthous stomatitis Death Dysesthesia (1980): Russell IJ, Ann Intern Med 92, 716 Dysgeusia (<1%) Glossitis (<1%) Gynecomastia (1983): Kapoor A, JAMA 250, 2284 Headache Hypersensitivity (<1%) (potentially fatal)
Oral lichenoid eruption (1983): Hamburger J+, BMJ 287, 1258 Oral mucosal eruption (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1977): Calabro JJ+, Clin Pharmacol Ther 22, 358 (3%) Oral mucosal erythema (1979): Anderson RJ, N Engl J Med 300, 735 Oral ulceration Paresthesias (<1%) Pseudolymphoma (2000): Werth V, Dermatology Times 18 Rectal mucosal ulceration (2002): Cruz-Correa M+, Gastroenterology 122(3), 641 Serum sickness (1984): Stern RS+, JAMA 252, 1433 Stomatitis (<1%) (1991): Renaut JJ, Allerg Immunol Paris (French) 23, 365 (1978): Brogden R+, Drugs 16, 97 Tinnitus Xerostomia (1980): Smith F+, JAMA 244, 269 (1978): Huskinson L+, Ann Rheum Dis 37, 89
Trade name: Imitrex (GSK) Other common trade name: Imigrane Indications: Migraine attacks Category: Antimigraine; Serotonin agonist Half-life: 2.5 hours Clinically important, potentially hazardous interactions with: citalopram,
dihydroergotamine, ergot-containing drugs, escitalopram, fluoxetine, fluvoxamine, isocarboxazid, MAO inhibitors, methysergide, naratriptan, nefazodone, paroxetine, phenelzine, rizatriptan, sertraline, sibutramine, St John’s wort, tranylcypromine, venlafaxine, zolmitriptan
Reactions
Skin Angioedema
(1995): Dachs R+, Am J Med 99, 684
Burning (sic) (1-10%) Diaphoresis (1.6%) Erythema (<1%) Exanthems Flushing (6.6%) Hot flashes (>10%) Hot sensations (1991): Multiple authors, N Engl J Med 325, 316 Photosensitivity (<1%) Pruritus (<1%) Rash (sic) (<1%) Raynaud’s phenomenon (<1%) Sensitivity (sic) (1994): Black P+, N Z Med J 107, 20 Urticaria (1996): Pradalier A+, Cephalalgia 16, 280
Other Anaphylactoid reactions
Dysesthesia (<1%) Dysgeusia (<1%) (2001): Hershey AD+, Headache 41, 693 Glossodynia Headache Hyperesthesia (<1%) Injection-site reactions (sic) (58%) (1991): Multiple authors, N Engl J Med 325, 316 (10-20%) Myalgia (1.8%) Parageusia (<1%) Paresthesias (13.5%) Parosmia (<1%) Xerostomia
