ABSTRACT
Synonyms: TG; 6-TG; 6-thioguanine; tioguanine Trade name: Thioguanine (GSK) Other common trade name: Lanvis Indications: Leukemias Category: Antimetabolite; Antineoplastic Half-life: 11 hours Clinically important, potentially hazardous interactions with: aldesleukin,
vaccines
Reactions
Skin Exanthems
(1988): Zimm S+, J Clin Oncol 6, 696 Malignancies (sic) (1997): Zackheim HS+, J Am Acad Dermatol 30, 452 (nonmelanoma) Painful red hands (1988): Shall L+, Br J Dermatol 119, 249 Petechiae Photosensitivity (<1%) (1988): Zimm S+, J Clin Oncol 6, 696 Pruritus (1999): Silvis NG+, Arch Dermatol 135, 433 Psoriasis (1999): Silvis NG+, Arch Dermatol 135, 433 Purpura Rash (sic) (1-10%)
Hair Hair-alopecia
(1999): Murphy FP+, Arch Dermatol 135, 1495 (1988): Zimm S+, J Clin Oncol 6, 696
Other Oral mucosal lesions
Stomatitis (1-10%) Xerostomia (1999): Silvis NG+, Arch Dermatol 135, 433
Trade name: Thiopental (Baxter) Other common trade names:Anesthal; Hypnostan; Intraval; Nesdonal; Sodipental;
Trapanal Indications: Induction of anesthesia Category: Anticonvulsant; Barbiturate anesthetic; Sedative Half-life: 3-12 hours Clinically important, potentially hazardous interactions with: ethanol,
ethanolamine
Reactions
Skin Angioedema
(1975): Brown TP, Anaesth Intensive Care 3, 257 (1972): Almeyda J+, Br J Dermatol 86, 313 (1971): Fox GS+, Anesthesiology 35, 655 (1957): Hayward JR+, J Oral Surg 15, 61 Bullous eruption (1987): Saiag P+, Ann Dermatol Venereol (French) 114, 1440 (1977): Evans JM+, BMJ 2, 735 Erythema (<1%) Erythema multiforme (1947): Hunter AR, Lancet 1, 47 (1946): Peterkin GAG, BMJ 2, 52 Exanthems (1987): Boittiaux P+, Ann Fr Anesth Reanim (French) 6, 324 (3.3%) (1971): Fox GS+, Anesthesiology 35, 655 (1946): Peterkin GAG, BMJ 2, 52 Exfoliative dermatitis Fixed eruption (1995): Bremang JA+, Can J Anaesth 42, 628 (1990): Desmeules H, Anesth Analg 70, 216 (non-pigmenting) (1987): Saiag P+, Ann Dermatol Venereol (French) 114, 1440 Hypopigmentation (1979): Coote N+, Anaesthesia 34, 336 Pruritus (<1%) Purpura (1972): Almeyda J+, Br J Dermatol 86, 313 (1946): Peterkin GAG, BMJ 2, 52 Rash (sic) Shivering (1987): Boittiaux P+, Ann Fr Anesth Reanim (French) 6, 324 (27%) Stevens-Johnson syndrome (1946): Peterkin GAG, BMJ 2, 52 Toxic epidermal necrolysis (1987): Saiag P+, Ann Dermatol Venereol (French) 114, 1440 Urticaria (1972): Almeyda J+, Br J Dermatol 86, 313 (1972): Barjenbruch KP+, Anesth Analg 51, 113 (1957): Hayward JR+, J Oral Surg 15, 61 (1946): Peterkin GAG, BMJ 2, 52
Other Anaphylactoid reactions (<1%)
(2001): Garvey LH+, Acta Anaesthesiol Scand 45(10), 1204 (1993): Seymour DG, JAMA 270, 2503 (letter)
(1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 193 (passim)
(1988): Cheema AL+, J Allergy Clin Immunol 81, 220 (1975): Brown TP, Anaesth Intensive Care 3, 257 (1973): Kelly AJ+, Anaesth Intensive Care 1, 332 (1972): Barjenbruch KP+, Anesth Analg 51, 113 (1971): Davis J, Br J Anaesth 43, 1191 (1971): Sargent NW, Br J Anaesth 43, 591 Headache Injection-site necrosis Injection-site pain (>10%) Injection-site phlebitis (1981): Clark RSJ, Drugs 22, 26 (6%) Porphyria (1993): Harrison GG+, Anaesthesia 48, 1008-1010 (1976): Panica D+, Folia Med Plovdiv 18, 161 (1975): Mees DE+, South Med J 68, 29 (1966): Eales L, Anesthesiology 27, 703 Rhabdomyolysis (1990): Larpin R+, Presse Med 19(30), 1403 Thrombophlebitis (<1%) Twitching (<1%)
Trade name: Mellaril (Novartis) Other common trade names: Aldazine; Apo-Thioridazine; Calmaril; Dazine;
Melleril; Ridazin; Thinin; Thioril Indications: Psychotic disorders Category: Phenothiazine antipsychotic Half-life: 21-25 hours Clinically important, potentially hazardous interactions with: antihistamines,
arsenic, chlorpheniramine, dofetilide, epinephrine, piperazine, quinolones, sparfloxacin
Reactions
Skin Acanthosis nigricans
(1979): Arnold HL+, J Am Acad Dermatol 1, 93 Angioedema (<1%) (1964): Welsh AL, Med Clin North Am 48, 459
Dermatitis (sic) (1968): Wolpert A+, Clin Pharmacol Ther 9, 456 Erythema multiforme (1985): Rees TD, J Periodontol 56, 480 Exanthems (1974): Rothstein E, N Engl J Med 290, 521 Exfoliative dermatitis Hypohidrosis (>10%) Lupus erythematosus (1971): Fabius AJM+, Acta Rheumatol Scand 17, 137 Peripheral edema Photosensitivity (1-10%) (1987): Röhrborn W+, Contact Dermatitis 17, 241 (1976): Suhonen R, Contact Dermatitis 2, 179 Phototoxicity (1967): Satanove A+, JAMA 200, 209 (1960): Barsa JA+, Am J Psychiatry 116, 1028 Pigmentation (<1%) (blue-gray) (1970): Ayd FJ, Int Drug Ther Newsletter 5, 24 (1969): Berger H, Arch Dermatol 100, 487 Purpura Rash (sic) (1-10%) (1981): Georgotas A+, Psychopharmacology 73, 292 (1969): Doyle JA+, Curr Ther Res 11, 429 (1960): May RH+, J Nerv Mental Dis 130, 230 Seborrhea Toxic epidermal necrolysis (1987): Harnar TJ+, J Burn Care Rehabil 8, 554 Urticaria Vasculitis (2002): Greenfield JR+, Br J Dermatol 147(6), 1265 (confirmed on re-challenge) Xerosis
Hair Hair-alopecia
Hair-hypertrichosis (1979): Phillips P+, JAMA 241, 920
Other Anaphylactoid reactions
Death (2001): Glassman AH+, Am J Psychiatry 158(11), 1774 (2000): Timell AM, Ann Clin Psychiatry 12(3), 147 (4 cases) Galactorrhea (<1%) Gynecomastia Headache
Hypersensitivity Lymphoproliferative disease (1992): Aguilar JL+, Arch Dermatol 128, 121 Mastodynia (1-10%) Oral mucosal eruption (1985): Rees TD, J Periodontol 56, 480 Paresthesias Parkinsonism (>10%) Parotitis (1974): Rothstein E, N Engl J Med 290, 521 Porphyria (1985): Kamal S+, Union Med Can (French) 114, 330 Priapism (<1%) (2001): Compton MT+, Clin Psychiatry 62(5), 363 (passim) Pseudolymphoma (1988): Kardaun SH+, Br J Dermatol 118, 545 Tardive dyskinesia (1990): Miller LG+, South Med J 83(5), 525 (27%) Tremor Xerostomia (1981): Georgotas A+, Psychopharmacology 73, 292
Synonym: TSPA Trade name: Thioplex (Immunex) Indications: Breast, ovarian and bladder carcinomas Category: Antineoplastic Half-life: 109 minutes Clinically important, potentially hazardous interactions with: aldesleukin
Reactions
Skin Allergic reactions (sic) (1-10%)
Angioedema (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
292 (passim) (1987): Lee M+, J Urol 138, 143 (1985): Levine N+, Cancer Treat Rev 5, 67 (1981): Weiss RB+, Ann Intern Med 94, 66
(1969): Veenema RJ+, J Urol 101, 711 Bruising Ecchymoses Eccrine squamous syringometaplasia (1997): Valks R+, Arch Dermatol 133, 873 Leucoderma (1979): Harben DJ+, Arch Dermatol 115, 973 (passim) (1976): Rosai J+, Hum Pathol 7, 83 (1969): Berkow JW+, Arch Ophthalmol 82, 415 (periorbital) (1966): Reed RJ+, Arch Dermatol 94, 396 Pigmentation (1-10%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
292 (passim) (1989): Horn TD+, Arch Dermatol 125, 524 (1974): Hornblass A+, Ann Ophthalmol 6, 1155 (1969): Howitt D+, Am J Ophthalmol 68, 473 Pruritus (1-10%) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
292 (passim) (1987): Lee M+, J Urol 138, 143 (1985): Levine N+, Cancer Treat Rev 5, 67 (1981): Weiss RB+, Ann Intern Med 94, 66 (1969): Veenema RJ+, J Urol 101, 711 Rash (sic) (1-10%) Urticaria (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
292 (passim) (1987): Lee M+, J Urol 138, 143 (1985): Levine N+, Cancer Treat Rev 5, 67 (1981): Weiss RB+, Ann Intern Med 94, 66 (1977): Greenspan E+, JAMA 237, 2288 (3.8%) (1969): Veenema RJ+, J Urol 101, 711
Hair Hair-alopecia (1-10%)
(2002): de Jonge ME+, Bone Marrow Transplantation 30(9), 593 (permanent) (with carboplatin and cyclophosphamide)
(1966): Clavert W, BMJ 2, 831
Other Anaphylactoid reactions (<1%)
Injection-site pain (>10%) Stomatitis (<1%)
