ABSTRACT
Dysgeusia (<2%) Glossitis (<2%) Gynecomastia (<2%) Headache Limb pain (2001): Wright WL, Castro Valley, CA (from Internet) (observation) Myalgia (>3%) (2003): Guis S+, Arthritis Rheum 49(2), 237 (2003): Litt JZ, Beachwood, OH (personal case) (observation) (2003): Olsson AG+, Clin Ther 25(1), 119 (2.2%) (2002): Litt JZ, Beachwood, OH (personal observation) (2002): Patel DN+, J Heart Lung Transplant 21(2), 204 (2002): Sinzinger H, Wien Klin Wochenschr 114(21), 943 (2001): Litt JZ, Beachwood, OH (2 personal cases) (2001): Rehbein H, Jacksonville, FL (from Internet) (observation) (2001): Sorkin M, Denver, CO (from Internet) (observation) (2001): Wright W, Castro Valley, CA (from Internet) (2 observations) (1998): Malinowski JM, Am J Health Syst Pharm 55, 2253 Myopathy (2002): Leon Vazquez F+, Aten Primaria 30(3), 188 (2002): Phillips PS+, Ann Intern Med 137(7), 581 Myositis (2002): Patel DN+, J Heart Lung Transplant 21(2), 204 Oral ulceration (<2%) Paresthesias (<2%) Parosmia (<2%) Rhabdomyolysis (2003): Guis S+, Arthritis Rheum 49(2), 237
(2003): Mah Ming JB+, AIDS Patient Care STDS 17(5), 207 (with clarithromycin, and lopinavir/ritonavir)
(2003): Sipe BE+, Ann Pharmacother 37(6), 808 (with clarithromycin and esomeprazole)
(2002): Castro JG+, Am J Med 112(6), 505 (with delavirdine) (2002): Patel DN+, J Heart Lung Transplant 21(2), 204 (2000): Davidson MH, Curr Atheroscler Rep 2(1), 14 (1999): Bottorff M, Atherosclerosis 147(Suppl 1), S23 (1999): Maltz HC+, Ann Pharmacother 33(11), 1176 (with cyclosporine) Stomatitis (<2%) Tendinopathy (2001): Chazerain P+, Joint Bone Spine 68(5), 430
Trade names: Malarone (GSK); Mepron (GSK) Other common trade name: Wellvone Indications: Pneumocystis carinii infection Category: Antiprotozoal Half-life: 2.2-2.9 days Clinically important, potentially hazardous interactions with: rifampin
Reactions
Skin Diaphoresis (10%)
Erythema multiforme Exanthems (1993): Haile LG+, Ann Pharmacother 27, 1488 Pruritus (11%) (1996): Radloff PD+, Lancet 347, 1511 Rash (sic) (23%) (1993): Artymowicz RJ+, Clin Pharm 12, 563
Other Dysgeusia (3%)
Headache Oral candidiasis (1-10%)
