ABSTRACT
Indications: Arthritis, pain Category: Antipyretic; Nonsteroidal anti-inflammatory (NSAID) Half-life: 2-4 hours Clinically important, potentially hazardous interactions with: aspirin, diuretics,
methotrexate, NSAIDs, salicylates, tacrolimus, urokinase
Reactions
Skin Angioedema (<1%)
(1994): Halpern SM, Arch Dermatol 130, 259 (passim) (1987): Shelley ED+, J Am Acad Dermatol 17, 1057 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1984): Stern RS+, JAMA 252, 1433 (1982): Bailin PL+, Clinics in Rheumatic Diseases WB Saunders 8, 493 (passim) Bullous eruption (<1%) (1994): Halpern SM, Arch Dermatol 130, 259 (passim) (1988): Laing VB+, J Am Acad Dermatol 19, 91 (1984): Stern R+, JAMA 252, 1433 Bullous pemphigoid (1993): Fellner MJ, Clin Dermatol 11, 515 (1981): Pompeova L, Cesk Dermatol (Czech) 56, 256 Dermatitis (<1%) (1993): Ophaswongse S+, Contact Dermatitis 29, 57 (1986): Veronesi S+, Contact Dermatitis 15, 103 (1985): Valsecchi R+, Contact Dermatitis 12, 286 Dermatitis herpetiformis (1994): Tousignant J+, Int J Dermatol 33, 199 Diaphoresis (1974): Regalado RG+, J Int Med Res 2, 115 Eczema (sic) (1986): Veronesi S+, Contact Dermatitis 15, 103 Edema (<1%) Erythema multiforme (<1%)
(1995): Lesko SM+, JAMA 273, 929 (1994): Halpern SM, Arch Dermatol 130, 259 (passim) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
186 (passim) (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1985): O’Brien WM+, J Rheumatol 12, 13 (1984): Stern R+, JAMA 252, 1433 (1978): Sternlieb P+, N Y State J Med 78, 1239 Erythema nodosum (1994): Halpern SM, Arch Dermatol 130, 259 (passim) Exanthems (1994): Halpern SM, Arch Dermatol 130, 259 (passim) (1994): Litt JZ, Beachwood, OH (personal case) (observation) (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1980): Shoenfeld Y+, JAMA 244, 547 (1979): Finch WR+, JAMA 241, 2616 (1978): Sonnenblick M+, BMJ 1, 619 (1975): Blechman WJ+, JAMA 233, 336 (3.4%) (1974): Regalado RG+, J Int Med Res 2, 115 (0.86%) (1973): Mills SB+, BMJ 4, 82 (>5%) Fixed eruption (<1%) (2003): Litt JZ, Beachwood, OH (glans penis) (personal case) (pbservation) (2003): Litt JZ, Beachwood, OH (personal case) (observation) (2001): Diaz Jara M+, Pediatr Dermatol 18, 66 (2000): Zabawski E, Longview, TX (from Internet) (observation) (1998): Mahboob A+, Int J Dermatol 37, 833 (1996): Eichwald M, Redding, CA (from Internet) (observation) (1994): Shelley WB+, Cutis 53, 282 (observation) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
186 (passim) (1991): Kuligowski ME+, Contact Dermatitis 25, 259 (1990): Bharija SC+, Dermatologica 181, 237 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1984): Kanwar AJ+, J Dermatol 11, 383 (1984): Stern R+, JAMA 252, 1433 Flushing Hot flashes (<1%) Linear IgA bullous dermatosis (2002): Au S+, (Vancouver) (Canada) March AAD Poster Livedo reticularis (1979): Finch WR+, JAMA 241, 2616 Lupus erythematosus (1996): Vigouroux C+, Rev Med Interne (French) 14, 856 (1985): O’Brien WM+, J Rheumatol 12, 13 (1980): Bar-Sela S+, J Rheumatol 7, 379
(1978): Pereyo-Torrellas N, Arch Dermatol 114, 1097 (1978): Sonnenblick M+, BMJ 1, 619 (exacerbation) Pemphigus (1988): Laing VB+, J Am Acad Dermatol 19, 91 Periorbital edema (1979): Finch WR+, JAMA 241, 2616 Photosensitivity (1994): Berger TG+, Arch Dermatol 130, 609 (in HIV-infected) (5 cases) (1994): Halpern SM, Arch Dermatol 130, 259 (passim) (1992): Bergner T+, J Am Acad Dermatol 26, 114 (1990): Bergner T+, J Allergy Clin Immunol 85, 177 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1982): Bailin PL+, Cllnics in Rheumatic Diseases WB Saunders 8, 493 Pruritus (1-5%) (1994): Halpern SM, Arch Dermatol 130, 259 (passim) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford, 186 (passim) (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1-5%) (1979): Finch WR+, JAMA 241, 2616 (1975): Blechman WJ+, JAMA 233, 336 (1.8%) Psoriasis (palms) (1986): Ben-Chetrit E+, Cutis 38, 45 (exacerbation) (1985): Bigby M+, J Am Acad Dermatol 12, 866 Purpura (1969): Ward T, BMJ 4, 430 Rash (sic) (>10%) (1974): Regalado RG+, J Int Med Res 2, 115 Stevens-Johnson syndrome (<1%) (1994): Halpern SM, Arch Dermatol 130, 259 (passim) (1978): Sternlieb P+, N Y State J Med 78, 1239 Toxic epidermal necrolysis (<1%) (1994): Halpern SM, Arch Dermatol 130, 259 (passim) (1980): Sternlieb P+, Ann Intern Med 92, 570 Urticaria (>10%) (2001): Diaz Jara M+, Pediatr Dermatol 18, 66 (1994): Halpern SM, Arch Dermatol 130, 259 (passim) (1993): Litt JZ, Beachwood, OH (personal case) (observation) (1987): Shelley ED+, J Am Acad Dermatol 17, 1057 (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1984): Stern RS+, JAMA 252, 1433 (1982): Bailin PL+, Clinics in Rheumatic Diseases WB Saunders 8, 493 (passim) (1975): Blechman WJ+, JAMA 233, 336 (0.2%) Vasculitis (2001): Davidson KA+, Cutis 67, 303 (bullous leukocytoclastic) (1996): Peters F+, J Rheumatol 23, 2008
(1994): Halpern SM, Arch Dermatol 130, 259 (passim) (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
186 (passim) (1985): Bigby M+, J Am Acad Dermatol 12, 866 (1984): Stern R+, JAMA 252, 1433 (1982): Labbe A+, Ann Dermatol Venereol (French) 109, 995 (1978): Pereyo-Torrellas N, Arch Dermatol 114, 1097 Vesiculobullous eruption (1992): Breathnach SM+, Adverse Drug Reactions and the Skin Blackwell, Oxford,
186 (passim) (1988): Laing VB+, J Am Acad Dermatol 19, 91 (passim)
Hair Hair-alopecia (<1%)
(1985): O’Brien WM+, J Rheumatol 12, 13 (1979): Meyer HC, JAMA 242, 142 Hair-disorders (sic) (1994): Halpern SM, Arch Dermatol 130, 259 (passim)
Nails Nails-changes (sic)
(1994): Halpern SM, Arch Dermatol 130, 259 (passim) Nails-onycholysis (1982): Bailin PL+, Clinics In Rheumatic Diseases WB Saunders 8, 493
Other Anaphylactoid reactions (<1%)
(2001): Verma S, Baroda, India (from Internet) (observation) (with acetaminophen) (2000): Takahama H+, J Dermatol 27, 337 (1998): Menendez R+, Ann Allergy Asthma Immunol 80, 225 (1985): O’Brien WM+, J Rheumatol 12, 13 (1979): Finch WR+, JAMA 241, 2616 Aphthous stomatitis Death (2001): Stevenson R+, Scott Med J 46(3), 84 DRESS syndrome (2001): Descamps V+, Arch Dermatol 137, 301 Embolia cutis medicamentosa (Nicolau syndrome) (2003): Reding EL+, J Am Acad Dermatol 48(3), 472 (passim) Gingival ulceration (<1%) Gynecomastia (<1%) Headache Hypersensitivity (2001): McMahon AD+, J Clin Epidemiol 54(12), 1271 (1981): Ruppert GB+, South Med J 74, 241 Impaired wound healing
(1988): Proper SA+, J Am Acad Dermotol 18, 1173 Myopathy (1987): Ross NS+, JAMA 257, 62 Oral lichenoid eruption (1983): Hamburger J+, BMJ 287, 1258 Oral mucosal lesions (1974): Regalado RG+, J Int Med Res 2, 115 Oral ulceration (1974): Regalado RG+, J Int Med Res 2, 115 Paresthesias Pseudolymphoma (2001): Werth V, Dermatology Times 18 Pseudoporphyria (2000): De Silva B+, Pediatr Dermatol 17, 480 (1992): Petersen CS+, Ugeskr Laeger (Danish) 154, 1713 Rhabdomyolysis (1989): Menzies DG+, Med Toxicol Adverse 4(6), 468 Serum sickness (1995): Lesko SM+, JAMA 273, 929 Stomatitis Tinnitus Xerostomia (<1%)
Trade name: Corvert (Pharmacia) Indications: Atrial fibrillation and flutter Category: Antiarrhythmic class III Half-life: 2-12 hours
Reactions
Skin Bullous eruption
Dermatitis (1998): Dodds ES+, Pharmacotherapy 18, 880 (bullous)
Other Headache
Torsades de pointes (2002): Gowda RM+, Am J Ther 9(6), 527
