ABSTRACT
A variety of chemicals, drugs, and herbal derivatives possess anticholinergic properties defined by their ability to block the neurotransmitter acetylcholine (ACh). This effect is a result of a direct interference with either of two types of cholinergic receptors — peripheral muscarinic or nicotinic receptors. Anticholinergic effects are also a consequence of adverse drug reactions (ADR), as seen with the tricyclic and phenothiazine antidepressants. In addition, many anticholinergic compounds exert their action by occupying central cholinergic receptors, thus producing alterations upon the CNS.
