ABSTRACT
CVD is the number one killer of the human population, which is also indicative of the vital functions of the CV system. Included within functions of the CV system are (1) cardiac pumping ability, including the rhythmic nature of the electrical signals, force of contraction, and magnitude of the discharge pressure; (2) integrity of the vasculature, including muscular tone and structural integrity of vessel walls, and the tight regulation of blood pressure; and (3) blood volume and composition, including water and electrolyte balance, lipid composition, and capabilities of clot formation and lysis. These functions are compromised, to varying extents, in CVD, which can be modified therapeutically or prophylactically with a number of drugs. The proper use of the CV drugs has greatly reduced the mortality and morbidity caused by CVD. On the other hand, many CV drugs have the potential to cause toxicity, particularly when used inappropriately or in overdoses. As such, a greater understanding of the clinical toxicology of CV drugs will contribute to our ability to effectively manage CVD. This chapter will discuss the clinical toxicology of commonly used CV drugs.
