ABSTRACT
Short Bowel Syndrome as an Important Clinical Problem ..................................187 Intestinal Adaptation..............................................................................................188 Potential Mechanisms of Gut Adaptation .............................................................190 Specific Nutrients as Methods to Enhance Intestinal Growth, Repair, and Adaptation ..........................................................................................191 Administration of Recombinant Growth Factors in Animal Models of SBS.......................................................................................................192 Studies on the Efficacy of GH, GLP-2, Gln and/or Modified Oral Diet to Enhance Intestinal Rehabilitation in Human SBS ...................................193 References..............................................................................................................199
Massive small bowel resection (SBR) is a major cause of intestinal failure in adults and children. In adults, relatively common conditions such as Crohn’s disease, splanchnic ischemia, repeated abdominal operations, and trauma might require massive or repeated SBR, thus leading to SBS.1,2 Patients with SBS exhibit chronic diarrhea and malabsorption, and varying degrees of dehydration, weight loss, protein-energy and micronutrient depletion, weakness, and decreased quality of life.3-8 In addition, patients with SBS commonly require chronic or intermittent parenteral nutrition (PN) to prevent severe malnutrition.1-2,7-11 Unfortunately, PN is expensive
