ABSTRACT
Solid lipid nanoparticles (SLN) have attracted increasing scientific and commercial attention during the last few years. This chapter highlights the main features of SLN, including the concept of SLN, different methods of production, and their applications. Special attention is paid to the relation among drug incorporation, the heterogeneity of the lipid particle, and the presence of other colloidal species. Strategies of SLN stabilization to avoid particle growth or gelation are discussed. The biological fate of the particles and the suitability of SLN for drug targeting are reviewed.
