ABSTRACT
The salicylates are, in comparison with other NSAIDs and analgesics, of relatively low toxicity when taken at therapeutic dosages (Lamont-Havers and Wagner, 1966; Smith, 1966; Cuthbert, 1974; Rainsford, 1975a; 1989a; 1997a; 1997b; Miller and Jick, 1977; Rainsford and Velo, 1984; 1987; 1992; Freie, 1996) (see Tables 8.1 and 8.2), and this is probably one of the main features accounting for the success of this group of drugs. Yet the discovery (or rediscovery), of some minor side effects at various times leading to concern about the safety of these drugs, usually leads to improved understanding about the relative importance of these effects.
