ABSTRACT
Antibiotics have long been, and remain, a major cause of drug-related renal toxicity, causing both acute renal failure and tubulointerstitial disease, depending on the drug. Most cases of acute renal failure are related to acute tubular necrosis, for which aminoglycosides have long been one of the leading causes. Tubulointerstitial disease is more commonly seen with β-lactams (hypersensitivity nephropathy), but can also be caused indirectly by aminoglycosides (tubulointerstitial injury).
