chapter  12
35 Pages

Sample Size Calculation in Other Areas

As indicated earlier, sample size calculation is an integral part of clinical research. It is undesirable to observe positive results with insufficient power. Sample size calculation should be performed based on the primary study endpoint using appropriate statistical methods under a valid study design . with correct hypotheses, which can reflect the study objectives. In the previous chapters, we have examined formulas or procedures for sample size calculation based on various primary study endpoints for comparing means, proportions, variabilities, functions of means and variance components, and time-to-event data. In this chapter, in addition, we discuss several procedures for sample size calculation based on different study objectives and/or hypotheses using different statistical methods, which are not covered in the previous chapters.