chapter  4
33 Pages

Large Sample Tests for Proportions

The remaining sections of this chapter are organized as follows. In the next section, a general procedure of power analysis for sample size calculation for testing one-sample problem is given. Sections 4.2 and 4.3 summarize statistical procedures for sample size calculation for a two-sample problem under a parallel-group design and a crossover design, respectively. Sections 4.4 and 4.5 discuss statistical procedures for testing a multiple-sample problem under a parallel design and a crossover design (Williams design), respectively. Formulas for sample size calculation for comparing relative risks between treatment groups under a parallel design and a crossover design are given in Section 4.6 and 4.7, respectively. Section 4.8 provides some practical issues regarding sample size calculation for comparing proportions in clinical research.