ABSTRACT
Slowly oxidizes in aqueous solutions containing dissolved oxygen to azoprocarbazine and hydrogen peroxide.2
Mode of Action
Procarbazine is an alkylating agent that reacts with RNA.3,4
Physiological Properties and Health Hazards
Animal carcinogen. Reasonably anticipated to be a human carcinogen and when used as a chemotherapeutic agent in combination with nitrogen mustard, a potent animal carcinogen, can result in acute nonlymphocytic leukemia.5 Adverse effects in 50-70% of
thrombocytopenia. LD50
Wear protective gloves, clothing, and goggles. Cover the spill with a 1:1:1 mixture by weight of soda ash, clay cat litter (bentonite), and sand. Scoop the mixture into a container. Estimate the amount of procarbazine hydrochloride, and add sufficient water to make an approximately 1% solution. For each 100 mg of procarbazine hydrochloride, add 6 g of calcium hypochlorite and stir at room temperature for 12 hours. Decant the liquid into the drain with a large volume of water, and treat the solid residue as normal refuse.1,6
Waste Disposal
Wear protective gloves, clothing, and goggles. Work in the fume hood. Dissolve the waste procarbazine hydrochloride in water to make an approximately 1% solution. For each 100 mg of procarbazine hydrochloride, add 6 g of calcium hypochlorite and stir the mixture for 12 hours. The solution can be poured into the drain with a large excess of water.1
