ABSTRACT
Ovarian hyperstimulation syndrome (OHSS) is the gravest complication of so-called controlled (far too often uncontrolled) ovarian hyperstimulation (COH).1 From a perspective of priorities in reproductive medicine in general and assisted reproductive technologies in particular, OHSS is second only to high-order multiple birth on the list of adverse outcomes that need to be minimized or completely eliminated. Ovarian hyperstimulation syndrome consists of ovarian enlargement accompanied by an overproduction of ovarian hormones and a host of other ovarian vasoactive substances, which alone or in concert may produce the hyperpermeability state responsible for the signs, symptoms, and complications of OHSS.
