ABSTRACT

As is the has been in the last decades a between products and technology. New products fult1ll new needs, open new markets, in turn, new develof,m ic:n1,s in process and industrialization. Sometimes they are

sometimes are a consequence of the of other technologies. This is the reason I shall switch from basic science to engineering and from technology to consumer without tolloWlng a strict ra1JOIQaJlty

I. BIOLOGICAL PRODUCTS AND PHARMACEUTICALS A. Some Basic Issues

Trp'P7f'-rlnl1inO has been essentially nn'~f"r\l" tll"',n of unstable biochemicals and. more The very first issue was, to secure their and their potency during processing, and reconstitution. At the outset most

were freeze-dried either as a natural substance, such are blood or or, for vaCCines,

as controlled concentrates of inactivated and/or living cells resulting from selected culture fermentation broths.