ABSTRACT
During a seizure, normal patterns of neuronal excitation are replaced by pathological rhythms that are excessively synchronized, prominent, and widespread. The capacity for seizure activity is latent in normal brain-for example, seizures can be provoked in anyone as a symptom of simple metabolic disturbances such as hypoglycemia, hypocalcemia, or uremia. What is intrinsically different about the brains of people with epilepsy, who exhibit seizures without such provocations?
