ABSTRACT

Seizure disorders represent a frequently occurring neurologic problem. Antiepileptic drugs (AEDs) are the primary treatment modality and provide good seizure control in most patients. However, more than 25% of children and adults with seizure disorders have either intractable seizures or suffer significant adverse effects secondary to medications. A limited number will benefit from surgical therapy. The shortcomings of antiepileptic drug therapy have allowed alternative treatments to emerge. In this chapter, I will review three specific and unique treatments of special interest to the epileptologist (pyridoxine, acetazolamide, and magnesium sulfate).