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50 1.37 0.25 1.33 0.12 1.28 0.06 1.26 0.05 1.26

Example 9.8: During a pharmacokinetic study it was found that a drug is removed from the body exclusively by biotransformation and that the relationship expressing the decrease of the drug concentration in plasma is

where Vmax=0.60 (µg/ml)/h and KM=0.10 µg/ml. Calculate the time required for the decline of drug concentration from 30 to 18 µg/ml.