ABSTRACT
In the history of therapy for Parkinson’s disease (PD), there is no more important event than the discovery of levodopa-replacement therapy. The introduction of this agent in 1967 (1) was nothing short of a revolution in the treatment of PD. Very early in the use of levodopa it became apparent that the drug had remarkable efficacy in treating the major motor symptoms of PD, that it was associated with certain adverse events, and that it was not a cure, nor did it appear to slow progression of PD. It was a powerful and extremely useful symptomatic treatment.
