ABSTRACT
Surgical treatment of movement disorders has markedly expanded in the past decade because of our enhanced understanding of basal ganglia circuitry and pathophysiology of Parkinson’s disease (PD). Advancements in neuroimaging [especially magnetic resonance imaging (MRI)] and intraoperative electrophysiological recordings have increased stereotaxic surgical targeting accuracy. Abnormal subthalamic nucleus (STN) activity has been implicated to be important in the genesis of the clinical features of PD. Altering this aberrant activity using STN deep brain stimulation (DBS) has been effective for moderate to advanced PD with sustained benefit for several years.
