Autografting with unmanipulated stem cells: The European experience Arnaud Pigneux, Eduardo Olavarria, François X Mahon, Josy Reiffers
Autologous stem cell transplantation (ASCT) was ﬁrst attempted for patients with CML in transformation in order to restore a second chronic phase. In 1978, Buckner et al1 used bone marrow harvested during the chronic phase to rescue haematopoiesis after a supralethal myeloablative conditioning regimen including totalbody irradiation (TBI). Subsequently, Goldman et al2 reported that peripheral blood progenitor cells collected at diagnosis could be used efﬁciently to reconstitute haematopoiesis after similar conditioning. The results of ASCT for CML in transformation have been extensively reviewed,3-7 and can be summarized as follows:
• Haematopoietic recovery is faster after peripheral blood than bone marrow stem cell transplantation.