ABSTRACT

Finally, when all medical approaches have

failed, anti-obesity surgery may be considered

in severely obese well selected diabetic patients

(Figure 2.1).9

It is obvious that insulin resistance plays a key

role in the intimate relationship between

obesity and diabetes.14 However, not all obese

subjects will develop diabetes and it is well

PATIENT EVALUATION – Degree of hyperglycaemia – Associated risk factors

LIFESTYLE MODIFICATIONS

DRUG PRESCRIPTION

Anti-obesity compounds

Anti-risk factor compounds

Anti-diabetic compounds

Sibutramine Orlistat

Antihypertensive agents Hypolipidaemic drugs

Oral agents Insulin

BARIATRIC SURGERY

(in selected patients)

– Diet VLCDs – Exercise

established that a defect in insulin secretion is

mandatory for the expression of the disease.15