ABSTRACT
Finally, when all medical approaches have
failed, anti-obesity surgery may be considered
in severely obese well selected diabetic patients
(Figure 2.1).9
It is obvious that insulin resistance plays a key
role in the intimate relationship between
obesity and diabetes.14 However, not all obese
subjects will develop diabetes and it is well
PATIENT EVALUATION – Degree of hyperglycaemia – Associated risk factors
LIFESTYLE MODIFICATIONS
DRUG PRESCRIPTION
Anti-obesity compounds
Anti-risk factor compounds
Anti-diabetic compounds
Sibutramine Orlistat
Antihypertensive agents Hypolipidaemic drugs
Oral agents Insulin
BARIATRIC SURGERY
(in selected patients)
– Diet VLCDs – Exercise
established that a defect in insulin secretion is
mandatory for the expression of the disease.15