ABSTRACT
Historically, the prefrontal cortex has been symbolically described using a multitude of vivid metaphors, ‘uncharted provinces of the brain’, being a typical example. Recently, however, cognitive and brain scientists have begun to unravel the mysteries of the frontal lobe, yielding what must now be one of the most exciting and important areas of research in contemporary neuroscience. The fact that the functional anatomy of this region has remained unclear for so long can be attributed to two general principles. First, while the frontal lobe undoubtedly contributes to many aspects of cognition and behavior, it does so via reciprocal connections with many other cortical and subcortical regions. Thus, while studies of patients with frontal lobe damage have implicated this region in functions as diverse as attention, memory, language, planning, social cognition and motor control, the specificity of this contribution often remains in some doubt; patients with damage to posterior cortical regions, for example, often exhibit behavioral changes reminiscent of those observed after frontal lobe damage. Second, the frontal cortex is not a homogeneous region of the brain but comprises several cytoarchitectonic areas that differ in terms of their connections with other cortical and subcortical areas. Relative to the enormous amount of information that is available about the structural and functional organization of the monkey brain, very little is known of the connections between specific cortical areas in humans. Even with the advent of high-resolution structural imaging, in patient studies it is often not possible to relate any particular area of the frontal cortex to a given cognitive process with any degree of anatomical precision, since the excisions are rarely confined to specific cytoarchitectonic areas. Rather than attempting a broad-brush overview of this complex field, this chapter focuses on three interrelated neuropsychological themes that have emerged as consistent hallmarks of the so-called ‘frontal lobe syndrome’; namely, deficits of planning, attentional ‘set’ and memory. In each case, the specificity of the frontal lobe impairment will
be considered, together with related evidence from functional neuroimaging.
